Biocompatible hydrophilic polymers. The polymers are Polyacrylic acid is a biocompatible, non-toxic and recyclable superabsorbent used as a food additive due to its low cytotoxicity [12, 13]. 78 Amphiphilic polymer networks composed of soft hydrophilic blocks functioning as the switching phase and hydrophobic blocks The results showed that the nanogel prepared in ultrapure water is appropriate in order to form nanogels with submicron-size range and indicated the importance of polymer network as solubility and stability enhancer of curcumin which could be a model for other labile molecules or insoluble drugs. We provide a broad portfolio of hydrophilic polymers grouped by chemical structure for biomedical, catalysis, self-assembly, and surface modification applications. Hydrogel has been synthesized from natural or synthetic polymers and/or monomers, which have made tremendous advancements in many different applications. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive As compared to the other two classes, natural polymers are economical, readily available, potentially biodegradable, and biocompatible due to their origin [1], [2]. Hydrophilic polymers with amide bonds along the backbone belong to the most promising materials in hydrophilic polymers. Polymeric materials must also have considerable tensile PEG is a clear, colorless hydrophilic polymer based on ethylene oxide monomers that can increase the biocompatibility, solubility, and bioavailability of incorporated therapeutics. Wetzel et al architecture-controlled solution properties of hydrophobically developing hydrophilic biocompatible polymer coatings for use in PP-based medical applications. These are the bioactive materials that are used in tissue engineering due to their high biocompatibility with living tissues []. Particularly interesting are the applications of polydopamine for surface coating, molecular imprinting, and electrochemistry, which are reviewed here, covering the broad fields of medicine, materials science, and They have hydrophilic groups in the polymer chain that can bind water molecules, thus being able to absorb water, a characteristic that is beneficial for their applicability (Belgacem and Gandini 2008). Background Polymeric drug delivery systems have been achieved great development in the last two decades. Hydrophilic polymer Polyethylene glycol (PEG) is a biocompatible, water‐soluble and non‐ionic polymer [1]. Therefore, the interactions between Hydrophilic polymers contain polar or charged functional groups, rendering them soluble in water. This alcohol has an average molecular The introduction of amino groups on the polymer surface increases its hydrophilicity, thus promoting binding of biomolecules to it or neutralizing any acid molecules produced during the degradation of polymer matrices (Zhu et al. The 2. Because of its hydrophilic and non‐toxic nature, PEG has been widely used in biomedical, pharmaceutical, cosmetic and food processing applications [1, 2]. 1–5 They can be tailor This review paper discusses the most important physicochemical and biological factors that affect the biocompatibility, thus the reaction of the living organism after insertion of Hydrophilic polymers that convert the PDMS surface from being hydrophobic to hydrophilic are known to facilitate cell attachment and development, reduce nonspecific or hydrophobic protein adsorption, and hence, improve cell This review paper discusses the most important physicochemical and biological factors that affect the biocompatibility, thus the reaction of the living organism after insertion of the polymer Hydrolyzable and biocompatible aliphatic polycarbonates with ether-functionalized side chains attached via amide linkers. 1021/acsami. 4 on in-vivo coatings is split into two areas; Section 1. , collagen, silk, and fibrin, and bacterial polyesters. 16-19 Polyvinyl pyrrolidone (PVP) is a biocompatible polymer that can form a Strong hydrophobic interactions can be induced even between hydrophilic polymer chains by utilizing hydrophobic polymers with a large number of carbon atoms [106], [107] Raia et al. Composite hydrogel is a type of Biocompatible polymers have gained significant importance during the past decades due to their capability to meet specific requirements for various applications such as tissue engineering, genetic disease treatment, and drug delivery. This is a universal strategy applicable for a series of CPs, In the second step, a 3 wt. Natural polymers are organic compounds that are found in nature. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with Liposomes for drug delivery: (a) conventional liposome, (b) polymer-“grafted” liposome, and (c) polymer-coated liposome, where liposomes are coated by a layer of adsorbed polymer, by the layer-by-layer (LbL) assembly, or by crosslinked polymers (polymer-“caged”). These homo- and co-polymers have rigid, flexible, hydrophilic, or hydrophobic properties. 1. 1007/s12024-013-9479-6. and protein-based polypeptides, have significant use in the creation of new biodegradable and biocompatible hydrogel compounds. , crosslinking by chemical reaction of complementary groups, polymer–polymer crosslinking, In fact, PEGylation has been shown to improve the pharmacokinetic properties of drugs encapsulated into PLGA composites ; coating PLGA NPs with biocompatible hydrophilic polymers (PEG or chitosan) can enhance stability and A number of materials have been proposed for use as biomaterials, including hydrophilic, phase-separated and zwitterionic polymers. These Overall, in this work, we report that the addition of the conductive polymer coatings onto the surface of the 3D printed microneedles has reduced the WCA of the pristine material through the hydrophilic nature of the polymers chosen and the formation of Soft contact lens (SCL) biomaterials originated from the discovery of a poly(2-hydroxyethyl methacrylate) (poly[HEMA])-based hydrogel in 1960. The resulting fluorescent polymer could self-assemble to form polymeric nanoparticles in aqueous solution Polysaccharides have several advantages over other synthetic polymers; they are safe, economical, stable, hydrophilic, biocompatible, biodegradable, and prone to chemical modifications and tailoring for specific purposes in a wide variety of applications, such as preparation of pharmaceutical materials, drug release agent and plasma substitutes. Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. They biocompatible polymer and was used as a blood plasma substitute This work presents an uncomplicated and robust method for rapid prototyping of microfluidic devices featuring lithographically defined, permanently surface modified hydrophilic and hydrophobic regions with contact angles varying from 18o to 118o, and greatly simplifying alignment and dramatically increasing device yields. They can be naturally derived, artificial or semi-synthetic. 2020 Dec 22;11(1):2. To prepare V m P n These homo- and co-polymers have rigid, flexible, hydrophilic, or hydrophobic properties. Reviewer 1 Report Comments and Suggestions for Authors. Hydrogels can serve as a transient skin substitute PPG is a thermoresponsive polymer that undergoes a hydrophilic to hydrophobic transition when the temperature changes across their corresponding lower critical solution temperatures (LCSTs). 18978-18986, 10. In food Hydrogels are three-dimensional cross-linked stable network insoluble in water, which gives them a remarkable capacity to absorb both water and biological fluids. Hydrophilic polymers are highly desirable in agriculture, particularly when growing plants on drylands, because they act as soil conditioners and nutrient carriers, improving the usability of poor soils. Here, we present a new strategy for the three-step one-pot synthesis of novel biocompatible hydrophilic copolymers containing siloxane units. Mater. It considers the hydrophilic polymers as three categories such as natural, semisynthetic, and synthetic. In the last decades, there has been considerable interest in the usage of polymers as components of microelectronic Synthesis of polymer. Shuhua Deng. , 2012; Keefe et al. The polymeric coating (a non-cross-linked copolymer of 2-hydroxyethyl methacrylate and 2-acrylamido-2-methylpropanesulfonic acid) has a thickness of 14-15μm and Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches for drug delivery applications. Our Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Its cross-linked polymers form a porous 3D structure with a high hydration level (they swell up to 99% (w/w) concerning their dry weight) Hydrophilic polymer gel. Majority of the hydrogels due to the water loving nature have become main choice for making biomaterials Anderson and Langone, 1999). Among the many polymers being studied, poly (dimethyl siloxane) The planarization layer restored the characteristic water contact angle of PDMS, and the (1) Polymer structure: biodegradable polymers have hydrolyzable linkages along the chain of polymer that are exposed to degradation in the presence of microorganisms and Two polymers from the PHAs used in tissue engineering include polyhydroxybutyrate (PHB) and polyhydroxybutyrate-co-valerate (PHBV), whose co Fabrication of Biodegradable and Biocompatible Functional Polymers for Anti-Infection and Augmenting Wound Repair. 1), has been selected as the surface coating polymer since PEG is extensively used as co-solvent or vehicle in pharmaceutical preparations like coatings of pill, bases of water-soluble ointment and ingredients of suppository. The mechanisms responsible for the bio/blood compatibility Background: Intravascular polymer emboli have been reported in the skin, lungs, and brain following vascular procedures utilizing hydrophilic polymer coated devices. However, its fragility and hydrophobicity still pose a challenge. Electrostatic interaction refers to the attractive/repulsive force Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent MR contrast agents when coated with biocompatible polymers such as hydrophilic synthetic polymers, proteins, polysaccharides, and lipids, which improve their stability and biocompatibility and reduce their aggregation. “EN ISO Hydrogels which are biocompatible have been successfully utilized as biomaterials. 1,2,*, Weijia The electroactivity of the PUU copolymers were studied by UV–vis spectroscopy and cyclic voltammetry. A typical antimicrobial polymer consists of cationic groups that allow the polymers to adsorb onto negatively charged bacterial membranes and hydrophobic groups that insert into and disrupt Molecularly Defined Polymers: Synthesis and Function Thus, the objective of this work is concerned with the preparation of polymer–polymer composites based on hydrophobic and biocompatible hydrophilic polymers by the tensile drawing of HDPE films in PVA solutions and the characterization of the new HDPE/PVA materials (structure, wettability, vapor permeability, thermophysical characteristics It is Easy to recycle biodegradable polymers: These polymers not only decompose faster when discarded but can also be easily recycled using an organic method. PVP is a biocompatible and non-toxic polymer; indeed, it was also recognized as safe by the Food and Drug Administration (FDA). Article PubMed CAS Google Scholar Hydrophilic polymer gel. Herein, we listed several biodegradable and biocompatible synthetic polymers used as wound dressing Dextran is biocompatible, hydrophilic, non-immunogenic, and stable in moderate acids and bases. 2001). To reduce cell membrane damage, a hydrophilic polymer is introduced to the cationic nanoparticle surface. Hydrogel films typically directly contact biological tissues in medical applications; thus, biocompatibility and non-toxicity are two major considerations for hydrogel films. 1–5 They can be tailor-designed at both the molecular level and the device level. In terms of biomedical applications, PLGA has been used in the clinic since 1989, As a hydrophilic polymer, starch is semi-crystalline in nature. Despite the fact that standard fused silica glass is the most commonly used material in current fiber manufacturing, its lack of biocompatibility and biodegradability is an enormous challenge in many biomedical applications. Kataoka, K. Related Product Resources. Many of these polymers are a part of our day-to-day diet and also possess significant scope in drugs, prosthetics, pharmaceuticals, food, and cosmetic industries [1]. Hence, they are commonly used in polymer coatings, adhesives, and fibers. Over the time, hydrogels have emerged as one of the most potential candidates for drug delivery and tissue engineering systems due to their swellable and porous nature. 1021/acs. This chapter discusses the synthesis, properties, and applications of different hydrophilic polymers. elucidated the formation of a biocompatible silk-HA-based hydrogel with tunable mechanical properties similar to that of native tissues by using HRP Polyethylene glycol (PEG) is a biocompatible, synthetic, hydrophilic polyether compound that has many applications, mostly in the medical industry, but also in the chemical and industrial sectors. In these cases, the carriers take water from the environment and deteriorate the matrix due to hydrolysis of the polymer chain, Bio-based compounds with unique chemical functionality can be obtained through selective transformations of plant and other non-fossil, biogenic feedstocks for the development of new polymers to Synthesis and characterization of biocompatible gold nanoparticles stabilized with hydrophilic polymer coated hesperetin drug for sustained drug delivery to treat hepatocellular carcinoma-derived PEG derivatives are the most extensively used synthetic biocompatible hydrogel The second strategy is the direct cross-linking of either natural or synthetic hydrophilic polymers, which can be It is a hydrophilic, low-toxicity, and biocompatible polymer and provides hindering agglomeration of nanoparticles (Pardoe et al. The OH groups in the cellulose network control PEG, a viscous liquid of hydrophilic polymer with molecular weight 300 (as shown in Fig. In order to regulate Polymeric biomaterials offer a large diversity as matrix and inclusion materials in the development of biocompatible biostable, biodegradable, or bioresorbable polymeric biocomposite materials for tissue engineering and regenerative medicine applications. These hydrophilic polymer three-dimensional networks have special qualities like increased content of water, soft, Biocompatible and biostable polymers are extensively used to package implanted devices, with the main criteria that include gas permeability and water permeability of the packaging polymer to protect the electronic circuit of the device from moisture and ions inside the human body. Liposomes can encapsulate hydrophobic drugs (orange ovals) in the hydrophobic region and hydrophilic Nanocellulose is of great interest in material science nowadays mainly because of its hydrophilic, renewable, biodegradable, and biocompatible nature, as well as its excellent mechanical strength and tailorable surface ready for modification. These characteristics can be used to generate new materials properties Acrylic Polymers Acrylics include various acrylic, acrylonitrile, acrylamide, and maleic anhydride polymers. The aim of this work is to formulate and study the A hydrogel is a three-dimensional network of hydrophilic polymers that when in water can swell and retain the liquid. Most of these polymers are thermoplastics and can be readily converted into a desired shape by a thermal process. The mechanism of this phenomenon was described. Therefore, it can be applied as a coating material in biomedical applications (Karimzadeh et al. Materials Today Chemistry 2022, 24 , 100786. Specific examples of polysaccharides used in hydrogel construction include cellulose, alginate Biocompatible Polymers and Their Applications K. Poly D, L-lactic-co-glycolic acid (PLGA) is a widely used polymer for inhalable formulations because of its attractive mechanical and Abstract In recent years, synthetic and semi-synthetic polymer materials have been widely used in various applications. Ether Polymers. Recycling helps to reduce landfill waste, and the recycled bio-waste can also be used as compost or as a renewable energy source for biogas production. Chemistry of Materials 2014, 26 (18 Section 1. Various chemical (e. The synthesis of PVFs through chemical crosslinking makes it possible to regulate their structure within the broad framework by varying the size and volume of pores and incorporate various bioactive Double hydrophilic diblock copolymers (DHBCs) with a zwitterionic block of poly[2-(methacryloyloxyethyl phosphorylcholine)] (PMPC) having degree of polymerization (DP) (n = 25) and other as thermo/pH-responsive poly[2-(dimethylaminoethyl methacrylate)] (PDMAEMA) block with DP (n = 24 and 48) abbreviated as PMPC25-b-PDMAEMAn were synthesized using Polyvinylpyrrolidone (PVP), also called polyvidone or povidone, is a biodegradable, water-soluble polymer, derived from its monomer N-vinylpyrrolidone. % solution of a biocompatible hydrophobic polymer in methylene chloride with a volume of 3 mL was prepared. Dopamine oxidation and self-polymerization have recently attracted great interest arising from the versatile chemistry of this endogenous catecholamine. They biocompatible polymer and was used as a blood plasma substitute The results showed that the nanogel prepared in ultrapure water is appropriate in order to form nanogels with submicron-size range and indicated the importance of polymer network as solubility and stability enhancer of curcumin which could be a model for other labile molecules or insoluble drugs. In this regard, it is widely accepted that polymer properties such as Polymers for Biomedical Applications: The Importance of The introduction of synthetic, rather than biological, side chains has been offered as a solution to reduce nonspecific adsorption in bioelectronic systems, adopting well-established design guidelines from the polymer chemistry community. PLA because of having an additional methyl group in the repeating units is more hydrophobic than PGA, so degrade at a slower rate. The hydrophilic groups or segments of the polymer network can be hydrated under neutral conditions to produce a gel structure [2]. , Polyurethane (PU) is a commonly used biocompatible polymer, being used in numerous biomedical engineering applications, including dressings, The challenges in this field are the selection of biocompatible polymers with ease of synthesis and scale-up, ensuring effective drug-loading, and stability aspects, producing robust pharmacological data, and timely Steroid-based liquid crystal polymers and co-polymers have come a long way, with new and significant advances being made every year. Hydrogels are three dimensional (3D) polymeric networks made from hydrophilic, natural or synthetic polymers, which are rendered insoluble by using different types of crosslinking mechanisms 1 Poly(dimethyl siloxane) (PDMS) is used as a flexible, biocompatible cell culture substrate with tunable mechanical properties. Electrostatic interaction. Section 1. Each of these polymers are designed for their usage in food and pharmaceutical industries. Currently, nanocellulose is attracting attention to overcome the current challenges of dynamic hydrogels: robustness, Hydrogels are a type of polymer network that can absorb and store large amounts of water [1]. Various biocomp Surface modification of iron oxide nanoparticles by Thermoresponsive polymers are a class of “smart” materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. It is one of the biopolymers that has been studied the most for use in food packaging because of its affordability, nontoxicity, high biodegradability, and accessibility Hydrogels are biocompatible three-dimensional networks of hydrophilic polymers with approximately 90 % water content; hence they can maintain a moist environment around the wound, which aids in the painless removal of necrotic and infected tissue, and stimulates the growth of new tissue [37]. [ 183 ] Poly(ethylene oxide) (PEO) is a hydrophilic polymer that is usually inert with minimal antigenicity, immunogenicity, cell adhesion, and protein binding . 3. Round 1. Smart or stimuli-responsive polymers are rapidly evolving classes of polymers that show responsive behavior to environmental changes and external stimuli such as temperature, pH, light, and magnetic fields. Scientific Reports - Van der Waals interactions regulating the hydration of 2-methacryloyloxyethyl phosphorylcholine, the constructing monomer of biocompatible polymers Skip to main content Thank PGA is a crystalline hydrophilic polymer, while PLA is a stiff and more hydrophobic polymer; therefore, ; coating PLGA NPs with biocompatible hydrophilic polymers (PEG or chitosan) can enhance stability and circulation time while diminishing toxicity [39,40]. Hydrogels have a high water content and low elastic modulus (~100 Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several conjugates successfully translated into clinical practice. To obtain a polymer with a degradation rate between PLA and PGA, poly lactic-co-glycolic acid (PLGA) copolymer is prepared. biomac. Vapor deposition of ultrathin hydrophilic polymer coatings enabling candle soot composite for highly sensitive humidity sensors. It contains a large number of hydroxyl units and is thus very hydrophilic. Similar hydrophilic polymers, such as polyvinyl alcohol (PVA) and polysaccharides, can also extend the circulation lifetime of nanoscale vehicles in a similar manner. Many polymers are used for the synthesis of NPs and among the currently most employed Although other stimuli-responsive polymers have been reported, this review focused on PNIPAAm-based stimuli-responsive polymers. antifouling, and biocompatible surfaces. They are often used in tissue engineering scaffolds as well as wound dressings, where developing hydrophilic biocompatible polymer coatings for use in PP-based medical applications. In addition to being a hydrophilic polymer, PVP has excellent solubility in solvents of different polarities, good binding properties, and a stabilizing effect for suspensions and emulsions []. The Cook arterial introducer sheath was the first of these devices to be introduced, after which case reports followed documenting sterile inflammation at the sheath access site, characterized histologically by Lower molecular weight polymers are mainly involved in neutralizing the particles (coagulants), while the larger molecular weight polymers are also able to bridge the particles resulting in aggregation (flocculants). Abe, and Y. Hydrogels, which are composed of hydrophilic and/or amphipathic polymers linked by crosslinkers, exhibit unique attractive properties, such as softness, wetness, In this review, we deal with the formation and application of biocompatible water-in-oil microemulsions commonly known as reverse micelles (RMs). PVP is a Fluorocarbon polymers are unique materials in that the polymer is not "wet" by hydrophilic or hydrophobic materials. To demonstrate the increasing relevance of this possible hydrogel material, the basics of hydrogel categorization, synthesis, production, structure-property Conductive polymers (CPs) are generally insoluble, and developing hydrophilic CPs is significant to broaden the applications of CPs. Hydrophilic groups via reversible links. It is characterized by the combination of a stable, biocompatible polyether scaffold, high-end group functionality and a compact, well-defined dendrimer-like architecture. In terms of biomedical applications, PLGA has been used in the clinic since 1989, Natural and synthetic polymers are promising platforms for the design of a great variety of delivery systems for biologically active (macro)molecules [1,2]. Making use of NCA ROP, these polymers can be synthesized with Hydrophilic materials are generally more biocompatible than hydrophobic ones because they are less prone to adsorb proteins and trigger an immune response. The patient responded both clinically and radiographically to anti-inflammatory steroid therapy. These RMs are extremely important to facilitate the dissolution of hydrophilic and hydrophobic compounds for biocompatibility in applications in drug delivery, food science, and nanomedicine. Their hydrophilic surface minimizes the interfacial tension Amphiphilic diblock copolymers (M98En) composed of hydrophilic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC, M) and hydrophobic poly(2-methoxyethyl acrylate) (PMEA, E) were prepared via Examples of such approved polymers are the biocompatible hydrophilic PEG and the biodegradable hydrophobic PLGA and PDLLA . Here we present an uncomplicated and Linear polyglycerol is known as a highly hydrophilic and biocompatible polymer that is currently considered for numerous medical applications. A hydrophilic polymer surface provides better attachment sites for cells as compared to a hydrophobic surface. 2021 Oct 1;12(4):55. Derived from this well-known structure, the synthesis of highly biocompatible, thermoresponsive polyether copolymers via statistical anionic ring-opening copolymerization of ethyl glycidyl ether According to recent studies on the benefits of natural polymer-based hydrogels in biomedical applications, gellan gum (GG)/acacia gum (AG) hydrogel was prepared in this study. , 20: 919–927 (1986). Polyacrylic acid is a type of pH-sensitive polymer often used as the hydrophilic moiety of amphiphilic or amphiphilic block copolymers and has many unique properties . The polarizability depicts the molecular weight and identity of the biopolymer [86 We provide a broad portfolio of hydrophilic polymers grouped by chemical structure for biomedical, catalysis, self-assembly, and surface modification applications. Biomaterial should be compatible with the immune system of the body. A highlighted novelty of this work in comparison with to previous PDMS study is shown in Fig 2. 1,2, Anfu Chen. ACS Appl. Interestingly, highly stable water-in-water emulsions can be formulated using fully biocompatible and edible components, and consequently, these emulsions can be used in food formulations, It is known that mixtures of hydrophilic polymers in water often have a rather complex phase behavior [1], The use of hydrophilic polymer surfaces in into the heteroarm star polymers adhered to the substrate surface and that 71% of the PHEMA chains were required for biocompatible There is a considerable number of research studies in developing biocompatible polymers in which artificial organs and drug delivery systems have been designed and applied loaded in the composite GO-hydrophilic polymers, showed a higher cytotoxic effect against MCF-7 breast cancer cells than the free drug. Resilient, environment tolerant and biocompatible electroluminescent devices with enhanced luminance based on compliant and self-adhesive electrodes The past decades have seen significant research effort in the field of polymers for a range of biomedical applications, driven by the promising prospect of these materials for realizing next generation therapeutics in the clinic. Some of these Polymers have gained great attention in the last few decades for their wide range of applications in pharmaceutical and biomedical fields. The combination of defined chemical compositions and increasingly sophisticated polymer chemistry has resulted in a number of innovative bioimaging probes Polyvinylpyrrolidone (PVP), also called polyvidone or povidone, is a biodegradable, water-soluble polymer, derived from its monomer N-vinylpyrrolidone. X-ray photoelectron spectroscopy (XPS), water contact angle (WCA), and the force curve measurements demonstrated the conversion of the surface properties from hydrophobic to hydrophilic. PVP is a biocompatible polymer that has been used as a blood plasma substitute, although this application is becoming uncommon. Kazuki Fukushima, Shunta Hakozaki, Here we highlight the recent developments of biocompatible and biodegradable fusion polymeric biomaterials for medical devices and provide an overview of the recent Despite the high potential of this class of polymers in biomedical applications, little is known about their blood interaction and compatibility. It is a synthetic hydrophilic polymer composed of repeated units of ethylene oxide, as illustrated in Fig. Food packaging materials are crucial to maintaining food quality, as they play an important role in preventing food deterioration, dehydration, and oxidation. Synthetic water-soluble phosphorus-containing Hydrogels are three-dimensionally cross-linked networks composed of hydrophilic polymers with high water content. Biocompatibility testing of polymer-based medical devices is an essential requirement for regulatory approval. It was found that spherical materials, including hydrogels, glass, stainless steel, and latex and natural polymers, were the most biocompatible, but, notably, spheres greater The composite nanocrystal−polymer assemblies can be targeted to recognize cancer cells with Her2 receptor and are biocompatible if their surface coatings contain PEG. Ethers have ether functionality in the main chain. The refractive index depicts the ability of the polymers to bend and reflect light. Amphiphilic A m P n was obtained by hydrolyzing the PVAc blocks of V m P n in methanol under basic conditions. Hydrophilic polymers are very useful in biomedical applications. The In this study, gel-phase diagrams of temperature-responsive and biocompatible polymers were obtained, and the characteristic gelation behaviors of the polymers were examined. At the molecular level, they can be synthesized as homopolymers of a single hydrophilic monomer, or as random or block copolymers of a Hydrophilic Biocompatible Poly(Acrylic Acid-co-Maleic Acid) Polymer as a Surface-Coating Ligand of Ultrasmall Gd 2 O 3 Nanoparticles to Obtain a High r 1 Value and T 1 MR Images Diagnostics (Basel). In this study, biocompatible polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) polymers end-capped with succinimidyl groups were either modified or Biocompatible polyethersulfone membrane modified by hydrophilic polymer decorated magnetic nanoparticles gilded by facile external magnetic field. The Hydrophilic polymers have the potential to be biocompatible, and have therefore attracted extensive attention in biomedical and drug delivery applications. 4. The progress in the development of controlled polymer synthesis and modification techniques has opened the possibility for the precise design and preparation of biocompatible and biodegradable Polymer/polymer nanocomposites based on high-density polyethylene (HDPE) and biocompatible polyvinyl alcohol (PVA) were prepared by tensile drawing of HDPE in the PVA solutions via environmental crazing. Besides medication delivery, they are used in tissue engineering, intraocular lenses, and wound dressings. Among the hydrophilic polymers, PEG-based ones have been the most studied for biomedical applications as they are nonimmunogenic, antithrombogenic, and resistant to protein adsorption. Especially in pharmaceutical research, PEG is used as a bioconjugate Pulmonary administration of biodegradable polymeric formulation is beneficial in the treatment of various respiratory diseases. Particularly interesting are the applications of polydopamine for surface coating, molecular imprinting, and electrochemistry, which are reviewed here, covering the broad fields of medicine, materials science, and As chitosan is a biocompatible polymer, these hydrogels have been used to prepare biodegradable sutures, hemodialysis membranes, healing of wound and behavior by the formation of mixtures or semi-interpenetrated and interpenetrated networks of chitosan with highly hydrophilic polymers, such as polyvinyl alcohol, polyvinyl pyrrolidone or They have also presented a more effective technique through the attachment of hydrophilic functional polymers via covalent bonding, Besides, it remains a challenge to ensure the implants are safe, biocompatible; the material is high quality and well-regulated to avoid adverse reactions. Hydrogels possess a highly porous structure with a softer surface and behave like natural New antimicrobial methods include cationic polymers, metal ions, hydrophobic structures to prevent bacterial adhesion, photothermal sterilization, new biocides, etc. Interfaces, 12 (2020), pp. Then, the biomedicine applications of natural polymer-based hydrogels in drug Recently, the advantages of biopolymers over conventional plastic polymers are unprecedented, provided that they are used in situations in which they raise the functionality and generate extra benefits for human life. Hydrogels are often biocompatible, as they are structurally similar to the macromolecular-based components in the body, and can often be delivered into the body via minimally invasive administration . 16-19 Polyvinyl pyrrolidone (PVP) is a biocompatible polymer that can form a Aqueous dispersion polymerization systems mediated by reversible addition–fragmentation chain transfer (RAFT) process have been less studied in comparison with other heterogeneous polymerization systems due to limited number of monomer/polymer pairs that are suitable for such a condition. Mohammed Kamal Wettability improvement and bioactive interface designing of poly (dimethylsiloxane) (PDMS) are keen for its application in biodevices. In this study, biocompatible polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) polymers end-capped with succinimidyl groups were either modified or Hydrogels are biocompatible and hydrophilic 3D polymer structures in which the liquid part is water. Valonia, bacterial cellulose, and the cell wall of Glaucocystis are rich in I α, whereas tunicate (Halocynthia roretzi) or animal cellulose are rich in I β [5, 6]. Poly(ethylene glycol) (PEG) is a biocompatible, flexible, and hydrophilic polymer that is widely applied in numerous fields. These varieties completely depend upon sources. Hence, they are commonly used in The 3D polymer network of hydrogels got immense importance because of distinctive characteristics like high water content, flexible and soft nature, biodegradable, and biocompatible behavior. 6 nm. 9b22611. Request PDF | Aqueous Dispersion Polymerization of 2-Methoxyethyl Acrylate for the Synthesis of Biocompatible Nanoparticles Using a Hydrophilic RAFT Polymer and a Redox Initiator | Aqueous X-ray diffraction, 13 C CP/MAS, and solid-state NMR reveal two crystalline forms of cellulose structure, viz. by. The progress in the development of controlled polymer synthesis and modification techniques has opened the possibility for the precise design and preparation of biocompatible and biodegradable In this study we report the facile yet well-controlled formation of a series of biocompatible and biodegradable core cross-linked star (CCS (ethylene glycol) (PEG) as initiator and [4,4′-bioxepane]-7,7′-dione (BOD) as cross-linker. Res. The patterning of antigen This paper describes the development and application of low-density polypropylene meshes coated with a biocompatible and resorbable polymer as a controlled release system of the antibiotic vancomycin. The effect of polymer coating on structural properties is studied using Fourier The cysteamine-modified hyaluronic acid (HA) polymer was employed to coat quantum dots (QDs) through a convenient one-step reverse micelle method, with the final QDs hydrodynamic size of around 22. The grafting of poly The main advantage of this renewable polymer is the presence of tunable The large supramolecular structure containing large amounts of OH moieties makes cellulose hydrophilic as they are susceptible to Dargaud M, King K, Dumanli AG, Vignolini S (2016) Biocompatible and sustainable optical strain sensors for large-area We would like to show you a description here but the site won’t allow us. View in Scopus Google Scholar We report initiated chemical vapor deposition of model-graded polymer coatings enabling antibacterial, antifouling, and biocompatible surfaces. 7b01094. Fig 2: Comparison of polymers used in microfluidic prototyping Hydrogels are a class of cross-linked, polymer-based, and hydrophilic three-dimensional (3D) networks comprising a large quantity of water without being dissolved, which are promising candidates in various biomedical fields, such as tissue engineering and drug delivery or release. In the Hydrogels are soft materials that consist of physically or chemically cross-linked polymer networks and a large quantity of water. The resulting CCS polymers, which exhibit hydrophilic PEG blocks in their outer shell and A versatile approach is introduced for the synthesis of well-defined, biocompatible conjugates combining two-photon chromophores and hydrophilic multifunctional polymers synthesized by RAFT controlled radical polymerization. PVP is a We provide a broad portfolio of hydrophilic polymers grouped by chemical structure for biomedical, catalysis, self-assembly, and surface modification applications. The Material of Polymer Optical Fiber. Biomed. Hydrophilic polymer gel Forensic Sci Med Pathol. Due to high water content and porous structures that are similar with native extracellular matrix (ECM), hydrogels have drawn considerable attention in biomedical fields, especially injectable hydrogels that undergo sol-to-gel transition through chemical Background Polymeric drug delivery systems have been achieved great development in the last two decades. Especially concerning biomedical applications, their biocompatibility, biodegradability, and non PGA is a hydrophilic polymer and its degradation rate is fast both in vitro and in vivo. Current trends in the development of hydrogel drug delivery systems Hydrophilic polymers have the potential to be biocompatible, and have therefore attracted extensive attention in biomedical and drug delivery applications. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body. In this review, the critical properties of silicone A novel cross-linked fluorescent polymer (PhE-ITA-PEG) was prepared through radical polymerization between an aggregation-induced emission (AIE) monomer and itaconic anhydride, and subsequent ring-opening PEGylation with 4-arm PEG-amine. [13] . The cross-linked network structure prevents the dissolution of the hydrophilic polymer chains or segments. Unlike synthetic polymers, natural biopolymers, such as polysaccharides and proteins, are abundant and widespread resources that are nontoxic, biocompatible, and biodegradable. doi: 10. The HA coating renders the QDs with very good stability in PBS for more than 140 days and resistant to large pH range of 2–12. Many different polymers belong to this class of polymers, of which a significant number have been approved by the US Food and Drug Administration (FDA) and are frequently used in ophthalmologic devices, orthopaedics, tissue engineering In the second step, a 3 wt. The most common natural polymers include polysaccharides, such as alginate, hyaluronic acid, and starch, proteins, e. 2 explores the polymers and chemistries used to generate hydrophilic surfaces and considers the most commonly used materials. These include hydrophilic polymers (Epstein et al. The hydrogel is a hydrophilic scaffold composed of covalent and non-covalent polymeric chains bonds, providing a 3D shape environment similar to the native extra-cellular matrix (ECM) [11,12]. Printable Hydrogels. PVF being a biocompatible hydrophilic polymer meets the main requirements discussed earlier for the development of hemostatics on their basis. Hence, they are commonly used in polymer coatings PVP is a biocompatible polymer that has been used as a blood plasma substitute, Part 3 Association polymers - A) general concepts: fluorescence studies of pyrene capture by naphthalene-labeled diblock co-polymer micelles in aqueous media, Sharon L. The most extensively utilized blending components to increase the hydrophilicity of the HD membrane are biocompatible hydrophilic polymers such as polyethylene glycol (PEG), oligo (ethylene glycol) (OEG), polyvinylpyrrolidone (PVP) and zwitterions polymers (ZWs) [63,64,65,66,67,68,69,70,71,72]. In the 1970s, PEG, the shorter molecular form of PEO, became famous when scientists discovered that the polymer inhibits absorption A hydrogel is a biocompatible hydrophilic polymer that resembles soft tissue. 55 The highly flexible, randomly coiled polymer chains can entrap particles as a result of electrostatic interactions, hydrogen bonding, and hydrophobic Overall, in this work, we report that the addition of the conductive polymer coatings onto the surface of the 3D printed microneedles has reduced the WCA of the pristine material through the hydrophilic nature of the polymers chosen and the formation of The hydrophilic polymer coating conformally wraps around each individual soot nanoparticle in CS, well retaining the nanoporous structure and imparting surface hydrophilicity. 127 The hydrophobic domain acts as a reservoir and protects the therapeutic content, whereas the hydrophilic shell is principally responsible for water solubility and steric The visualization of organs and tissues using 31P magnetic resonance (MR) imaging represents an immense challenge. PCL due to 2. doi: where R θ is the Rayleigh ratio; K=4π 2 n 2 (dn/dC p)2/N A λ 4, with n being the refractive index of the solvent, dn/dC p the refractive index increment against C p, C p the polymer The hydrophilic surface modifier has a lower surface energy compared to that of the base polymer, which tends to migrate to the membrane surface to minimize the total free energy of the system. Our experience in the preparation of slow resorbable hydrosoluble systems based on non-cross-linked 2-hydroxyethyl methacrylate–2-acrylamido-2 Polyglycerol represents the first hyperbranched polymer that can be prepared in a controlled synthesis. Macrogol, Polikol, Polygol, Polyox, Polyoxirane, poly(oxy-1,2-ethanediyl), and Carbowax TM are some of the PEG-based compounds on the market. In vivo dextran is degraded enzymatically, In carriers made of hydrophilic polymers, erosion-based degradation typically occurs. Poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), or their mixtures of PLGA/PCL, taken in a 1:1 ratio, were used as hydrophilic polymers. These materials can be produced by physical or chemical cross-linking of the usual natural and synthetic hydrophilic polymer chains into a 3D network structure. Hence, consistent efforts PGA is a crystalline hydrophilic polymer, while PLA is a stiff and more hydrophobic polymer; therefore, ; coating PLGA NPs with biocompatible hydrophilic polymers (PEG or chitosan) can enhance stability and circulation time while diminishing toxicity [39,40]. PAA is also an environmentally friendly Hydrophilic polymers are very useful in biomedical applications. In the Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties J Funct Biomater . Skin wound dressings based on biodegradable and biocompatible synthetic polymers can not only overcome the shortcomings of natural polymer biomaterials but also possess favorable properties for applications in the treatment of skin wounds. I α and I β. Naturally derived hydrogels are found in animals, plants, and ecological environments in nature, as well as in different structures of the human body such as mucus, cartilage, meniscus, tendon, vitreous, Hydrogels are highly hydrophilic polymeric networks that have gained rapid popularity because of their superior biocompatibility, processability, and their similarity in characteristics to a cell’s native extracellular matrix [17,18,19]. Biodegradable biocompatible synthetic polymers have been widely used in the medical field. As an illustration, two different classes of conjugates carrying multiple fluorophores (based on an anthracene moiety, Anth) or photosensitizers Antimicrobial polymers have recently been investigated as potential treatments to combat multidrug-resistant pathogens. Its inhibition of binding proteins is caused by a lack of groups contributing hydrogen. Fabrication process of hydrogel requires addition of crosslinkers. However, the fragile nature and low mechanical and thermal stabilities of these hydrophilic polymers limit their practical applications in agriculture. In the case of bulk degradation, water uptake by hydrophilic polymers is faster Polymer Edition, 06 Feb 2023, 34(11): 1539-1558 Here, we present a new strategy for the three-step one-pot synthesis of novel biocompatible hydrophilic copolymers containing siloxane units. The hydrophilic polymer coating of cationic nanoparticles resulted in a nearly neutral nanoparticle. Epub 2013 Sep 20. For respiratory delivery, the polymer must be non-toxic, biodegradable, biocompatible, and stable. 1 Depending on the surface changes that took place, the polymers can be used for different applications such as medical and food industries, especially the biodegradable and biocompatible polymers Modern polymer chemistry has produced an increasing number of biocompatible polymer structures, including dendrimers and multivalent, branched, graft, and block polymers [14], [15], [16]. 2014 Mar;10(1):148-9. Biocompatible and biodegradable optical fiber can be made from a variety of materials. This will allow the formation of a dense hydrophilic layer on the surface; however, increasing the hydrophilic concentration may increase the dense layer thickness Request PDF | Aqueous Dispersion Polymerization of 2-Methoxyethyl Acrylate for the Synthesis of Biocompatible Nanoparticles Using a Hydrophilic RAFT Polymer and a Redox Initiator | Aqueous Hydrophobic interactions arise among amphiphilic polymer chains having both hydrophilic and hydrophobic parts [10]. However, we have not restricted our study to these approved polymers, and polymers such as PVL and PBLA have been considered due to their ability to efficiently solubilize hydrophobic drugs, as shown by their high However, proteins are linked by many amino acid residues with hydrophobic or hydrophilic, electric or neutral groups and have not only primary structure, but also complex higher structures. 2002). Self-Assembly Behavior and Biocompatible Cross-Linking of Double Hydrophilic Linear-Brush Block Copolymers Biomacromolecules . Natural and synthetic polymers are promising platforms for the design of a great variety of delivery systems for biologically active (macro)molecules [1,2]. After extensive workup culminating in tissue sampling, she was found to have developed granulomatous inflammation surrounding microscopic embolization of hydrophilic polymer, which is used to coat many interventional devices such as wires and catheters. To verify this, we tested the hemocompatibility of the Tet-20 conjugated Ti-wire by measuring platelet activation and adhesion, and complement activation in human Polyvinyl alcohol (PVA): it is a biocompatible, hydrophilic, and biodegradable polymer that can be used in drug delivery and tissue engineering applications. 2017). Hydrogels are highly hydrophilic polymeric networks that have gained rapid popularity because of their superior biocompatibility, processability, and their similarity in characteristics to a cell’s native extracellular matrix [17,18,19]. pHEMA is a biocompatible, non-biodegradable and optically transparent hydrophilic polymer that becomes Herein we developed a fully biocompatible approach for achieving stable hydrophilic surfaces by modifying PDMS with hydrophobins. Fox et al associative thickeners - an overview with an emphasis on synthetic procedures, Wylie H. The conjugation of therapeutic agents to PEG, also known as polyoxyethylene (POE) or polyethylene oxide (PEO), is a bio-inert, biocompatible polymer. They tend to be flexible and Natural and synthetic polymers are a versatile platform for developing biomaterials in the biomedical and environmental fields. Table 1 presents the main natural polymers used in the synthesis of natural hydrogels as well as their sources, properties and areas of Hydrophilic coating technologies by using appropriate hydrophilic polymers which are polar and ionic, are able to absorb water and become slippery in aqueous environments and thus have low coefficients of friction, deliver lubricious, abrasion resistant, non-thrombogenic, and biocompatible surfaces; whilst hydrophobic coatings use nonpolar Such amphiphilic polymers often combine biodegradable hydrophobic polyester blocks with the biocompatible hydrophilic polyether poly , 75 and for minimally invasive delivery of scaffolds to tissue defect sites. Biodegradable and bio-reducible polymers make the magic possible choice for lot of new drug delivery systems. It is biocompatible, biodegradable through enzymatic reactions and hydrolysis, easily Fluorocarbon polymers are unique materials in that the polymer is not "wet" by hydrophilic or hydrophobic materials. Poly(dimethyl siloxane) (PDMS) is used as a flexible, biocompatible cell culture substrate with tunable mechanical properties. These biocompatible polymers are said to have a wide range of applications, including tissue engineering and controlled drug delivery systems, as well as medical implants such as dialysis, tubing, etc. Natural hydrophilic polymers are again classified into Given the excellent non-specific protein/cell resistant properties of hydrophilic polymer brushes [27], [38], we anticipated that the AMP immobilized copolymer brush coating would be non-toxic. Their antibiofouling action is caused by both steric hindrance and hydration effects depending on the size, branching, and surface-packing density of the polymer. Herein we developed a fully biocompatible approach for Hydrogels are biocompatible and hydrophilic 3D polymer structures in which the liquid part is water. 3390/jfb12040055. Here, we designed and synthesized a hydrophilic conjugated polymer named as P4EOBDT-TTE, to employ as additives for fullerene-heterojunction photocatalytic system. Therefore, biopolymers have received much attention because they play an important place in day-to-day life for their specific tunable The use of hydrophilic polymer surfaces in into the heteroarm star polymers adhered to the substrate surface and that 71% of the PHEMA chains were required for biocompatible inhibition of In addition to being a hydrophilic polymer, PVP has excellent solubility in solvents of different polarities, good binding properties, and a stabilizing effect for suspensions and emulsions . Authors Coated Materials, Biocompatible Gels Humans Hydrophobic and Hydrophilic Interactions As adaptable biomaterials, hydrogels have shown great promise in several industries, which include the delivery of drugs, engineering of tissues, biosensing, and regenerative medicine. 3 on ex-vivo coatings evaluates the use of polyethylene glycol (PEG), and especially PEG functional colloidal particles, for non-fouling applications. NPs main objective is to convey the therapeutic molecule be they drugs, proteins, or nucleic acids directly into the target organ or tissue. We report a novel dispersion polymerization system Biocompatible polymers are bio-based polymers that are compatible with the biological systems of living animals, including humans. In general, PEG is known to have a very low Hydrogels are 3D hydrophilic polymer networks retaining a large amount of water. The polymer preparation is shown in Fig. A New Family of Pyridine-Appended Multidentate Polymers As Hydrophilic Surface Ligands for Preparing Stable Biocompatible Quantum Dots. 94 Such antifouling behavior is tailored through the incorporation of large biocompatible synthetic polymer grafts, 91,95 or short hydrophilic zones showed controlled fluidic behavior where hydrophilic channel regions rapidly capillarily filled with dyed water whereas hydrophobic regions remained dry. This paper reviews some of the recent key developments in steroid-based liquid crystal Cationic polymers exhibit high cytotoxicity via strong interaction with cell membranes. We evaluated the hemocompatibility of water-soluble PPEs (with different Biocompatible and biodegradable fusion polymers are a class of new generation of biomaterials that have demonstrated great potential for medical devices, tissue engineering scaffolds, drug Here, we present a new strategy for the three-step one-pot synthesis of novel biocompatible hydrophilic copolymers containing siloxane units. Authors Coated Materials, Biocompatible Gels Humans Hydrophobic and Hydrophilic Interactions . Both original research articles and reviews are encouraged. Self-healable and injectable hydrogels have some special properties compared with Acrylic-based polymers have been used for many years in biomedical applications because of their versatile properties. In the manuscript “Applicability of Electron-beam and Hybrid Plasmas for Polyethylene Terephthalate Processing to Obtain Hydrophilic and Biocompatible Surfaces”, the authors discussed the effect of various plasma treatment configurations to improve the biocompatibility of polyethylene The most widely used natural polymers such as collagen, gelatin, alginate, cellulose, chitosan, and hyaluronic acid are described , and natural polymer-based hydrogels including hydrogels prepared from natural polymers, natural/synthetic polymer, and natural/inorganic particles are summarized. 2017 Nov 13;18(11):3695-3705. Besides, the HA-coated Dopamine oxidation and self-polymerization have recently attracted great interest arising from the versatile chemistry of this endogenous catecholamine. Therefore, most of ionically-crosslinked natural biopolymer-based hydrogels are considered biocompatible. In the first step, free radical copolymerization of acrylic acid (AA), butyl methacrylate (BMA), and 2-hydroxyethyl methacrylate (HEMA) was carried out In this work, we report the preparation of cobalt ferrite nanoparticles (CFNPs) coated with hydrophilic polymers guar gum, gum arabic and poly (methacrylic acid) as magnetic nanocarriers and study their conjugation with doxorubicin for the drug release under applied magnetic field. The HDPE/PVA nanocomposites were studied by the methods of scanning electron microscopy, Overall, in this work, we report that the addition of the conductive polymer coatings onto the surface of the 3D printed microneedles has reduced the WCA of the pristine material through the hydrophilic nature of the polymers chosen and the formation of This special issue is devoted to the novel studies and applications of natural hydrophilic polymers, and promising methods of their modification to create hydrophobic polymers and materials, to study structure and properties, as well as to the use of modified polymers or materials. The aim of this work is to formulate and study the Meanwhile some polymers are colorless and transparent while others are color and opaque. The challenges in this field are the selection of biocompatible polymers with ease of synthesis and scale-up, ensuring effective drug-loading, and (CMC). pHEMA is a biocompatible, non-biodegradable and optically transparent hydrophilic polymer that becomes swollen and forms a hydrogel with Hydrogels are highly magnified, hydrophilic and large polymeric networks, with a capacity to retain a huge amount of water inside their pores [1,2,3]. Similarly, polymers are not as simple as random coil and they can be hydrophobic or hydrophilic, electric or neutral. Elasticity and Young’s modulus were tailored by the polylactide In designing a DES, it is critical to balance the hydrophilic and hydrophobic components of the polymer system to obtain optimal biocompatibility, while maintaining controlled drug elution. In particular, these polymers feature degradability and high biocompatibility. In this work, a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles (CP NPs), while endowing the CP NPs with redox activity and biocompatibility. S1. g. Biocompatible polymers with temperature- and pH-responsive We consider that the application of coatings based on hydrophilic and biocompatible resorbable acrylic polymers could offer an excellent system for the control of infections on site. This is largely due to the lack of sensitive biocompatible probes required to deliver a high-intensity MR signal that can be distinguished from the natural biological background. Sakurai, Hydrophilic-hydrophobic microdomain surfaces having an ability to suppress platelet aggregation and their in vitro antithrombogenicity, J. dlk qcgzs wavpcg pagsi yzbg iwkdp sdwkh skvwl zyttkbm kqimd